Researchers used human induced pluripotent stem cells placed on nanoscale 3D laser-printed structures to successfully replicate the neural network of the brain.
3D printing, also known as additive manufacturing, is becoming more and more common in some of the latest innovations. By constructing continuous layers of raw materials, such as plastics, metals, and ceramics, it has the key advantage of producing complex shapes or geometries that can hardly be constructed by more traditional techniques (such as grinding, engraving, or molding).
The research trend of bio-3D printing technology combined with the needs of clinical medicine is becoming more and more obvious, especially in neurosurgery brain tumors, skull repair, nerve and blood vessels, but the research has not yet been applied to the clinic. With the continuous development of biomaterials and cell technology, the application of bio3D printing technology in the field of neurosurgery will make breakthroughs.
This technology has the potential to change the healthcare industry. Doctors can use it to develop products that match the patient’s unique anatomy, and radiologists can develop exact replicas of the patient’s spine to help plan surgery; the possibilities of this technology are far-reaching, and these technologies are in the nerves The field of science has great potential.
Stem cells are multipotent elements, and all other cells with specific functions are produced by stem cells; in essence, they are the raw materials of the human body. Advances in the separation and production of human stem cells provide great potential for further understanding of human cell functions and utilization of their regeneration in diseases and trauma.
However, the traditional two-dimensional growth of derived neurons-using a flat petri dish-is itself a major confounding factor, because it cannot fully simulate the three-dimensional interactions in the body, nor the countless developments that exist in real organisms. clue.
In order to overcome this shortcoming, the MESO-BRAIN project funded by FET, led by Aston University, proposed a carefully designed interdisciplinary plan to assemble a 3D network that shows the in vivo activity patterns of neural cultures and is able to interact with These cultures interact accurately. This helps to observe and regulate the movement of individual elements through electrical stimulation.
A human-induced pluripotent stem cell-derived neural network can be constructed on a well-defined and reproducible 3D scaffold that can mimic brain activity, allowing thorough investigation of neural network development.
The MESO-BRAIN project will contribute to a deeper understanding of human disease progression, nerve growth, and promote the development of large-scale human cell-based assays to test the regulatory effects of pharmacological and toxicological compounds on neural network activity.
Researchers hope that in the future, this can give people a deeper understanding of how to treat neurological diseases such as Parkinson’s disease, dementia, and trauma. With the continuous cross-fusion of multi-disciplinary technological breakthroughs and biotechnology, regenerative medicine based on stem cells and biomaterials will become a new breakthrough in human life sciences and medical diagnosis and treatment in the future.
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Link to this article：Nanoscale 3D laser printing induced pluripotent stem cells
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